Embryonic Stem Cell could be the Cure to Male Infertility | Morulaa

From the use of embryonic stem cells, the Chinese scientists says that they have discovered the functioning sperm, that has been injected into the female mice eggs and resulted normal, fertile offspring. While the experts warned that the process needs more experiments before truing it on humans, the research may be a milestone some day to treat the male infertility. “If the research results to be safe enough to imply on humans, this platform could potentially come up with the fully functional sperm for artificial insemination or invitro fertilization methods,” told by the co-senior study author of  Nanjing Medical University. “As the available treatments do not have much results on many couples. To know more about stem cell research – Stem Cell Research in India

The team of the Institute of Zoology at the Chinese Academy of Sciences have published a peer reviewed journal cell stem cell. The Researchers experimented the stems cells taken from the mouse embryos and used it to create an immature sperm like cells, or spermatids. To prepare this the researchers had to expose the mouse embryonic stem cells to the chemical cocktail, that had coaxed the cells into changing to primordial germ cells. later they had to expose the germ cells which is like a precursor cells that can change into other type of cells, to testicular cells and sex harmones like testosterone. This way helped the germ cell to transform into the sperm-like cells with appropriate nuclear DNA and chromosomal content”. Later these sperm cells were injected into the mouse egg cells, creating embryos that have been implanted into female mice. The females were able to produce babies that can mate and give birth to the next generation. To learn the approval and regulation of stem – Seamless Approval and Simplified Regulations for Stem Cell

Other researchers state that what works biologically in mice may not be applicable to humans. “This research is potentially interesting but needs independent verification,” says Azim Surani, director of germline and epigenomics research at the University of Cambridge. “It also remains to be seen if this protocol could work with human stem cells because of the known differences between the mouse and human germline.”

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